Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 18/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4837560 | 0.91 | JAK2 (0.54) | ACVR1JAK2CCNE1CDK2FLT3 | |
| SCHEMBL5094827 | 0.85 | FLT3 (0.55) | JAK2CCNE1CDK2FLT3 | |
| SCHEMBL5090994 | 0.84 | JAK2 (0.51) | ACVR1JAK2CCNE1CDK2FLT3 | |
| SCHEMBL4629170 | 0.83 | ACVR1 (0.53) | ACVR1JAK2CCNE1CDK2FLT3 | |
| SCHEMBL5094718 | 0.83 | ACVR1 (0.62) | ACVR1JAK2 | |
| SCHEMBL29353435 | 0.83 | ACVR1 (0.83) | ACVR1 | |
| SCHEMBL21526401 | 0.83 | ACVR1 (0.83) | ACVR1 | |
| SCHEMBL5097217 | 0.82 | JAK2 (0.54) | JAK2CCNE1CDK2FLT3 | |
| SCHEMBL4628140 | 0.81 | JAK2 (0.53) | ACVR1JAK2CCNE1CDK2FLT3 | |
| SCHEMBL5097325 | 0.80 | FLT3 (0.55) | ACVR1JAK2CCNE1CDK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | claimed |
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | AURKA, AURKC, PLK1 | ACVR1 1609/4885JAK2 205/4885CCNE1 159/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.