Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 2/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 8/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.38 |
| ▸ | SYK | P43405 | 4/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | GSK3A | P49840 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3037801 | 0.80 | MEN1 (0.45) | ITKMEN1HTTKMT2AHSD17B10 | |
| SCHEMBL13221083 | 0.79 | GSK3B (0.53) | ITKIGF1RKDRAURKAAURKB | |
| SCHEMBL3284849 | 0.78 | JAK2 (0.42) | ITKRIPK2KCNH2DHODHMEN1 | |
| SCHEMBL13220910 | 0.76 | AURKA (0.43) | DHODHAURKAAURKBGSK3BSRC | |
| SCHEMBL13220896 | 0.75 | SYK (0.42) | ITKIGF1RKDRAURKAAURKB | |
| SCHEMBL13220985 | 0.75 | AURKA (0.42) | ITKAURKAAURKBGSK3BSRC | |
| SCHEMBL13220899 | 0.75 | AURKA (0.41) | ITKFGFR1KDRAURKAAURKB | |
| SCHEMBL13221260 | 0.75 | ITK (0.40) | ITKIGF1RFGFR1KDRAURKA | |
| SCHEMBL13220904 | 0.75 | ALK (0.49) | ITKIGF1RFGFR1KDRAURKA | |
| SCHEMBL3031923 | 0.74 | IGF1R (0.45) | ITKIGF1RFGFR1KDRAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008516973-A | — | — | 2008-05-22 | — | — | JP | claimed |
| EP-1812439-A2 | KINASE INHIBITORS | Takeda San Diego, Inc. (US) | 2007-08-01 | — | — | EP | claimed |
| WO-2006044687-A2 | KINASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-04-27 | — | — | WO | claimed |
| EP-1812439-A2 | KINASE INHIBITORS | Takeda San Diego, Inc. (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006044687-A2 | KINASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-04-27 | — | — | WO | disclosed |