Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 11/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 6/20 | 0.37 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.34 |
| ▸ | AGER | Q15109 | 1/20 | 0.34 |
| ▸ | CIT | O14578 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | STK16 | O75716 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.33 |
| ▸ | CDK11B | P21127 | 1/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MAPK4 | P31152 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5096164 | 0.84 | ROCK1 (0.45) | ROCK1MAPK8MAPK9MAPK10AGER | |
| SCHEMBL5096293 | 0.79 | ROCK1 (0.51) | ROCK1MAPK8MAPK9MAPK10CIT | |
| SCHEMBL5095954 | 0.76 | MAPK8 (0.57) | ROCK1MAPK8MAPK9MAPK10CIT | |
| SCHEMBL11938729 | 0.74 | ROCK1 (0.39) | ROCK1MAPK8 | |
| SCHEMBL14176037 | 0.74 | MAPK8 (0.65) | MAPK8MAPK9MAPK10CITDAPK3 | |
| SCHEMBL5096339 | 0.74 | MAPK8 (0.65) | MAPK8MAPK9MAPK10CITDAPK3 | |
| SCHEMBL2510492 | 0.73 | ROCK1 (0.38) | ROCK1MAPK8 | |
| SCHEMBL14193105 | 0.71 | ROCK1 (0.36) | ROCK1MAPK8MAPK9MAPK10 | |
| SCHEMBL5102030 | 0.70 | CDC7 (0.38) | ROCK1 | |
| SCHEMBL14176011 | 0.69 | MAPK8 (0.70) | MAPK8MAPK9MAPK10CITDAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399462-B2 | 4-[4-(4-benzyloxy-indol-1-yl)-pyrimidin-2-ylamino]-cyclohexanol; autoimmune, inflammatory, metabolic, neurological diseases as well as cancer and pain | ROCHE PALO ALTO LLC (US) | 2013-03-19 | — | — | US | disclosed |
| US-20080146565-A1 | JNK modulators | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146565-A1 | JNK modulators | MAPKAPK2, MAPKAPK3, MAP3K10 | ROCK1 497/4885MAPK8 40/4885MAPK9 43/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.