Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 12/20 | 0.67 |
| ▸ | MAPK9 | P45984 | 10/20 | 0.67 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.58 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7137698 | 0.96 | MAPK10 (0.62) | MAPK10MAPK9MAPK8ALOX5HPGD | |
| SCHEMBL5102944 | 0.85 | MAPK10 (0.74) | MAPK10MAPK9MAPK8ALOX5HPGD | |
| SCHEMBL5596240 | 0.83 | MAPK10 (0.78) | MAPK10MAPK9MAPK8ALOX5HPGD | |
| SCHEMBL4021479 | 0.83 | MAPK10 (0.72) | MAPK10MAPK9MAPK8HPGDCYP1A2 | |
| SCHEMBL5096760 | 0.82 | MAPK10 (0.64) | MAPK10MAPK9MAPK8ALOX5HPGD | |
| SCHEMBL2881183 | 0.81 | MAPK10 (0.76) | MAPK10MAPK9MAPK8HPGDMEN1 | |
| SCHEMBL4023149 | 0.81 | MAPK10 (0.67) | MAPK10MAPK9MAPK8ALOX5HPGD | |
| SCHEMBL1518642 | 0.81 | MAPK10 (1.00) | MAPK10MAPK9MAPK8ALOX5HPGD | |
| SCHEMBL2886417 | 0.81 | MAPK10 (0.81) | MAPK10MAPK9MAPK8ALOX5MEN1 | |
| SCHEMBL2884385 | 0.80 | MAPK10 (0.70) | MAPK10MAPK9MAPK8ALOX5HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470686-B2 | Method of inhibiting the expression and/or the activity of JNK | LABORATOIRES SERONO SA (CH) | 2008-12-30 | — | — | US | claimed |
| US-7259162-B2 | Benzazole derivatives and their use as JNK modulators | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2007-08-21 | — | — | US | claimed |