Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.59 |
| ▸ | CTSD | P07339 | 11/20 | 0.59 |
| ▸ | BACE2 | Q9Y5Z0 | 10/20 | 0.59 |
| ▸ | CTSE | P14091 | 1/20 | 0.53 |
| ▸ | REN | P00797 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5096678 | 0.95 | BACE1 (0.67) | BACE1CTSDBACE2CTSEREN | |
| SCHEMBL5090802 | 0.91 | BACE1 (0.57) | BACE1CTSDBACE2CTSEREN | |
| SCHEMBL5090833 | 0.89 | BACE1 (0.61) | BACE1CTSDBACE2CTSEREN | |
| SCHEMBL4891033 | 0.88 | BACE1 (0.61) | BACE1CTSDBACE2 | |
| SCHEMBL4884863 | 0.88 | BACE1 (0.64) | BACE1CTSDBACE2REN | |
| SCHEMBL5094480 | 0.87 | BACE1 (0.79) | BACE1CTSDBACE2REN | |
| SCHEMBL4880356 | 0.87 | BACE1 (0.70) | BACE1CTSDBACE2REN | |
| SCHEMBL5096664 | 0.85 | BACE1 (0.75) | BACE1CTSDBACE2REN | |
| SCHEMBL5097081 | 0.85 | BACE1 (0.63) | BACE1CTSDBACE2CTSEREN | |
| SCHEMBL5103020 | 0.84 | BACE1 (0.64) | BACE1CTSDBACE2REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051420-A1 | New Compounds 317 | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | US | claimed |
| US-20080051420-A1 | New Compounds 317 | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051420-A1 | New Compounds 317 | PSEN2, PSEN1, MAPT | BACE1 6/4885CTSD 2053/4885BACE2 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.