Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 20/20 | 1.00 |
| ▸ | DRD2 | P14416 | 17/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 18/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4879674 | 0.95 | DRD3 (0.91) | DRD3DRD2KCNH2 | |
| Hydrochloric Acid SCHEMBL4879731 | 0.94 | DRD3 (0.89) | DRD3DRD2KCNH2 | |
| SCHEMBL5110871 | 0.90 | DRD3 (1.00) | DRD3DRD2KCNH2 | |
| SCHEMBL5102764 | 0.90 | DRD3 (0.84) | DRD3DRD2KCNH2 | |
| SCHEMBL4770243 | 0.89 | DRD3 (0.80) | DRD3DRD2KCNH2 | |
| SCHEMBL5105864 | 0.89 | DRD3 (0.80) | DRD3DRD2KCNH2 | |
| SCHEMBL5111942 | 0.87 | DRD3 (0.79) | DRD3DRD2KCNH2 | |
| SCHEMBL5110803 | 0.87 | DRD3 (0.83) | DRD3DRD2KCNH2 | |
| SCHEMBL5104734 | 0.87 | DRD3 (0.77) | DRD3DRD2KCNH2 | |
| SCHEMBL5105103 | 0.87 | DRD3 (1.00) | DRD3DRD2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429579-B2 | Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents) | SMITHKLINE BEECHAM, PLC (GB) | 2008-09-30 | — | — | US | claimed |
| US-7429579-B2 | Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents) | SMITHKLINE BEECHAM, PLC (GB) | 2008-09-30 | — | — | US | disclosed |