Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 10/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.53 |
| ▸ | HTR1B | P28222 | 7/20 | 0.53 |
| ▸ | HTR1A | P08908 | 7/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 3/20 | 0.35 |
| ▸ | TNK1 | Q13470 | 2/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5098906 | 0.88 | HTR1D (0.54) | HTR1DSLC6A4HTR1BHTR1APARP1 | |
| SCHEMBL5088717 | 0.88 | HTR1D (0.54) | HTR1DSLC6A4HTR1BHTR1ACYP19A1 | |
| SCHEMBL5097863 | 0.85 | HTR1D (0.55) | HTR1DSLC6A4HTR1BHTR1APARP1 | |
| SCHEMBL5099025 | 0.85 | HTR1D (0.55) | HTR1DSLC6A4HTR1BHTR1APARP1 | |
| SCHEMBL5097776 | 0.84 | HTR1D (0.61) | HTR1DSLC6A4HTR1BHTR1ADRD2 | |
| SCHEMBL5090873 | 0.84 | HTR1D (0.59) | HTR1DSLC6A4HTR1BHTR1APARP1 | |
| SCHEMBL5092305 | 0.84 | HTR1D (0.56) | HTR1DSLC6A4HTR1BHTR1APARP1 | |
| SCHEMBL5093551 | 0.83 | HTR1D (0.54) | HTR1DSLC6A4HTR1BHTR1ADRD2 | |
| SCHEMBL5092392 | 0.83 | HTR1D (0.54) | HTR1DSLC6A4HTR1BHTR1APARP1 | |
| SCHEMBL5092256 | 0.83 | HTR1D (0.55) | HTR1DSLC6A4HTR1BHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335660-B2 | Isochroman compounds for treatment of CNS disorders | ELI LILLY AND COMPANY (US) | 2008-02-26 | — | — | US | disclosed |
| US-20050014750-A1 | Isochroman compounds for treatment of cns disorders | ELI LILLY AND COMPANY | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014750-A1 | Isochroman compounds for treatment of cns disorders | INA, CNR2, CNR1 | HTR1D 201/4885SLC6A4 506/4885HTR1B 185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.