Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 15/20 | 0.50 |
| ▸ | CDK4 | P11802 | 6/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.44 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5096267 | 0.86 | CDK2 (0.51) | CDK2CDK4CDK1CCNT1CCNB1 | |
| SCHEMBL6105414 | 0.83 | CDK2 (0.74) | CDK2CDK4CDK1CCNT1CCNB1 | |
| SCHEMBL5095331 | 0.82 | CDK2 (0.59) | CDK2CDK4PLK1PLK3PLK2 | |
| SCHEMBL5105389 | 0.81 | CDK2 (0.72) | CDK2CDK4CDK1SYK | |
| SCHEMBL5095321 | 0.81 | CDK2 (0.54) | CDK2CDK4PLK1PLK3PLK2 | |
| SCHEMBL6105941 | 0.80 | CDK2 (0.71) | CDK2CDK4CDK1CCNT1CCNB1 | |
| SCHEMBL6417893 | 0.80 | CDK2 (0.63) | CDK2CDK4CDK1CCNT1CCNB1 | |
| SCHEMBL6595205 | 0.78 | CDK2 (0.58) | CDK2CDK4CDK1CCNT1CCNB1 | |
| SCHEMBL5096290 | 0.78 | PRKCD (0.53) | CDK2CDK4PLK1PLK3CDK1 | |
| SCHEMBL5102535 | 0.78 | CDK2 (0.52) | CDK2CDK4PLK1PLK3PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465728-B2 | Derivatives of 4-(imidazol-5-yl)-2-(4-sulfoanilino)pyrimidine with CDK inhibitory activity | ASTRAZENECA AB (SE) | 2008-12-16 | — | — | US | disclosed |
| CN-1649863-A | 4- (imidazol-5-yl) -2- (4-sulfoanilino) pyrimidine derivatives having CDK inhibitory activity | ASTRAZENECA AB (SE) | 2005-08-03 | — | — | CN | disclosed |
| US-20050131000-A1 | Derivatives of 4-(imidazol-5-yl)-2-(4-sulfoanilino)pyrimidine with cdk inhibitory activity | ASTRAZENECA AB (SE) | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050131000-A1 | Derivatives of 4-(imidazol-5-yl)-2-(4-sulfoanilino)pyrimidine with cdk inhibitory activity | CCNI, CDK2, CDK1 | CDK2 2/4885CDK4 5/4885PLK1 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.