SCHEMBL5100647

SCHEMBL5100647

CSCNC(C)=O

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18463758 0.79 TSHR (0.48)
SCHEMBL9056681 0.79 TSHR (0.55)
SCHEMBL6754719 0.78
SCHEMBL7724048 0.78
SCHEMBL24110821 0.77
SCHEMBL18660693 0.76
SCHEMBL13227782 0.74
SCHEMBL5313399 0.74
SCHEMBL5100639 0.74
SCHEMBL6961754 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080132496-A1 CARBOXYLIC ACID AMIDES, THE PREPARATION THEREOF, AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2008-06-05 US claimed
US-20040220169-A1 Carboxylic acid amides, the preparation thereof, and their use as pharmaceutical compositions BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2004-11-04 US claimed
EP-0477049-B1 Amido-3-pyrazole derivatives, process for their preparation and pharmaceutical compositions containing them SANOFI SYNTHELABO (FR) 1999-12-01 EP claimed
EP-0765307-B1 N ALPHA-2-(4-NITROPHENYLSULFONYL)ETHOXYCARBONYL-AMINO ACIDS HYUNDAI PHARM IND CO LTD (KR) 1999-10-20 EP claimed
EP-0765307-A1 N ALPHA-2-(4-NITROPHENULSULFONYL)ETHOXYCARBONYL-AMINO ACIDS Hyundai Pharm. Ind. Co., Ltd. (KR) 1997-04-02 EP claimed
US-5616788-A FOR SOLID PHASE PEPTIDE SYNTHESIS HYUNDAI PHARM. IND. CO., LTD. (KR) 1997-04-01 US claimed
WO-1996025394-A1 Nα-2-(4-NITROPHENULSULFONYL)ETHOXYCARBONYL-AMINO ACIDS HYUNDAI PHARM. IND. CO., LTD. (KR) 1996-08-22 WO claimed
US-12018003-B2 Substituted pyrimidines as matrix metalloproteinase-9 hemopexin domain inhibitors THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) 2024-06-25 US disclosed
US-20230303649-A1 MODIFIED IL-2 POLYPEPTIDES FOR TREATMENT OF INFLAMMATORY AND AUTOIMMUNE DISEASES BRIGHT PEAK THERAPEUTICS AG (CH) 2023-09-28 US disclosed
US-20210380546-A1 VACCINE ADJUVANT THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2021-12-09 US disclosed
EP-2827883-B1 TFPI INHIBITORS AND METHODS OF USE Baxalta GmbH (CH) 2019-05-08 EP disclosed
US-20170360794-A1 JAK INHIBITOR Wuxi Fortune Pharmaceutical Co., Ltd (CN) 2017-12-21 US disclosed
EP-3146977-A1 TFPI INHIBITORS AND METHODS OF USE Baxalta GmbH (CH) 2017-03-29 EP disclosed
CN-1173865-A Na-2- (4-nitrobenzenesulfonyl) ethoxycarbonyl-amino acids HYUNDAI PHARM IND CO LTD (KR) 1998-02-18 CN disclosed
EP-0765307-A1 N ALPHA-2-(4-NITROPHENULSULFONYL)ETHOXYCARBONYL-AMINO ACIDS Hyundai Pharm. Ind. Co., Ltd. (KR) 1997-04-02 EP disclosed
EP-0765307-A1 N ALPHA-2-(4-NITROPHENULSULFONYL)ETHOXYCARBONYL-AMINO ACIDS Hyundai Pharm. Ind. Co., Ltd. (KR) 1997-04-02 EP disclosed
US-5616788-A FOR SOLID PHASE PEPTIDE SYNTHESIS HYUNDAI PHARM. IND. CO., LTD. (KR) 1997-04-01 US disclosed
US-5616788-A FOR SOLID PHASE PEPTIDE SYNTHESIS HYUNDAI PHARM. IND. CO., LTD. (KR) 1997-04-01 US disclosed
WO-1996025394-A1 Nα-2-(4-NITROPHENULSULFONYL)ETHOXYCARBONYL-AMINO ACIDS HYUNDAI PHARM. IND. CO., LTD. (KR) 1996-08-22 WO disclosed
WO-1996025394-A1 Nα-2-(4-NITROPHENULSULFONYL)ETHOXYCARBONYL-AMINO ACIDS HYUNDAI PHARM. IND. CO., LTD. (KR) 1996-08-22 WO disclosed