Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.54 |
| ▸ | CDK8 | P49336 | 10/20 | 0.51 |
| ▸ | CDK7 | P50613 | 2/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CCND1 | P24385 | 1/20 | 0.51 |
| ▸ | CCNC | P24863 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | CCNH | P51946 | 1/20 | 0.51 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | FES | P07332 | 2/20 | 0.45 |
| ▸ | ROS1 | P08922 | 2/20 | 0.45 |
| ▸ | FER | P16591 | 2/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1873717 | 0.84 | KDR (0.53) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL14638748 | 0.82 | KDR (0.56) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL1873713 | 0.79 | KDR (0.48) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL3348784 | 0.78 | CDK8 (0.63) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL1869919 | 0.78 | CDK8 (0.63) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL27033549 | 0.77 | KDR (0.50) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL299515 | 0.77 | KDR (0.56) | RIPK1CDK8CDK7CCNT1CCND1 | |
| Hydrochloric Acid SCHEMBL7214988 | 0.77 | CDK8 (0.61) | RIPK1CDK8CDK7CCNT1CCND1 | |
| Hydrochloric Acid SCHEMBL16246682 | 0.77 | CDK8 (0.61) | RIPK1CDK8CDK7CCNT1CCND1 | |
| SCHEMBL29590039 | 0.76 | KDR (0.51) | RIPK1CDK8CDK7CCNT1CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371862-B2 | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2008-05-13 | — | — | US | disclosed |
| US-20070112020-A1 | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2007-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112020-A1 | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K20, MAP3K6, MAP3K1 | RIPK1 494/4885CDK8 30/4885CDK7 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.