Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.39 |
| ▸ | CDK9 | P50750 | 3/20 | 0.39 |
| ▸ | HASPIN | Q8TF76 | 3/20 | 0.39 |
| ▸ | PIM1 | P11309 | 3/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 6/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | CDK2 | P24941 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5101465 | 1.00 | CHEK1 (0.42) | CHEK1RPS6KB1AURKBAURKACCNT1 | |
| Hydrochloric Acid SCHEMBL5095195 | 0.98 | CHEK1 (0.41) | CHEK1RPS6KB1AURKBAURKACCNT1 | |
| Hydrochloric Acid SCHEMBL5095201 | 0.98 | CHEK1 (0.41) | CHEK1RPS6KB1AURKBAURKACCNT1 | |
| Trifluoroacetic Acid SCHEMBL5089583 | 0.93 | RPS6KB1 (0.38) | CHEK1RPS6KB1AURKBAURKACCNT1 | |
| Trifluoroacetic Acid SCHEMBL5089597 | 0.93 | RPS6KB1 (0.38) | CHEK1RPS6KB1AURKBAURKACCNT1 | |
| Hydrochloric Acid SCHEMBL5092721 | 0.92 | CHEK1 (0.40) | CHEK1RPS6KB1AURKBCCNT1CDK9 | |
| Hydrochloric Acid SCHEMBL5094592 | 0.92 | CDC7 (0.40) | CHEK1RPS6KB1AURKBCCNT1CDK9 | |
| Hydrochloric Acid SCHEMBL5092730 | 0.92 | CHEK1 (0.40) | CHEK1RPS6KB1AURKBCCNT1CDK9 | |
| Hydrochloric Acid SCHEMBL5094589 | 0.92 | CDC7 (0.40) | CHEK1RPS6KB1AURKBCCNT1CDK9 | |
| SCHEMBL4791548 | 0.86 | CDC7 (0.48) | CHEK1CCNT1CDK9HASPINKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7371862-B2 | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2008-05-13 | — | — | US | claimed |
| US-20070112020-A1 | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2007-05-17 | — | — | US | claimed |
| US-7371862-B2 | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2008-05-13 | — | — | US | disclosed |
| US-20070112020-A1 | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2007-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112020-A1 | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K20, MAP3K6, MAP3K1 | CHEK1 251/4885RPS6KB1 294/4885AURKB 170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.