Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 10/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 4/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14038734 | 0.91 | BRAF (0.47) | BRAFTMEM97SIGMAR1NAMPTKDM4E | |
| SCHEMBL5110302 | 0.90 | BRAF (0.62) | BRAFMAPK3MAPK1 | |
| SCHEMBL5110305 | 0.90 | BRAF (0.62) | BRAFMAPK3MAPK1 | |
| SCHEMBL5204343 | 0.90 | BRAF (0.62) | BRAFMAPK3MAPK1 | |
| SCHEMBL5114667 | 0.89 | TMEM97 (0.47) | BRAFTMEM97SIGMAR1NAMPT | |
| SCHEMBL5109890 | 0.88 | BRAF (0.47) | BRAFHRH3ALDH1A1LMNAMAPK3 | |
| SCHEMBL6761888 | 0.86 | BRAF (0.46) | BRAFTMEM97SIGMAR1NAMPTKDM4E | |
| SCHEMBL5204757 | 0.85 | BRAF (0.60) | BRAFMAPK3MAPK1 | |
| SCHEMBL5115997 | 0.85 | BRAF (0.60) | BRAFMAPK3MAPK1 | |
| SCHEMBL5115999 | 0.85 | BRAF (0.60) | BRAFMAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7452906-B2 | Pyridine derivatives as Raf kinase inhibitors | SMITHKLINE BEECHAM P.L.C. (GB) | 2008-11-18 | — | — | US | disclosed |
| EP-1423384-B1 | PYRIDINE DERIVATIVES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2007-05-23 | — | — | EP | disclosed |
| EP-1423384-A1 | PYRIDINE DERIVATIVES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003022840-A1 | PYRIDINE DERIVATIVES AS RAF KINASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 2003-03-20 | — | — | WO | disclosed |