Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | BCR | P11274 | 1/20 | 0.54 |
| ▸ | ACVR1 | Q04771 | 8/20 | 0.54 |
| ▸ | AURKA | O14965 | 9/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | CIT | O14578 | 1/20 | 0.42 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4629187 | 0.93 | ACVR1 (0.62) | ABL1BCRACVR1AURKAAURKB | |
| SCHEMBL4658010 | 0.91 | ABL1 (0.58) | ABL1BCRACVR1AURKAAURKB | |
| SCHEMBL4764362 | 0.90 | ACVR1 (0.55) | ABL1BCRACVR1AURKAAURKB | |
| SCHEMBL4629179 | 0.90 | ABL1 (0.55) | ABL1BCRACVR1AURKAAURKB | |
| SCHEMBL4763579 | 0.88 | ACVR1 (0.55) | ABL1BCRACVR1AURKAAURKB | |
| SCHEMBL5090825 | 0.84 | ABL1 (0.56) | ABL1BCRACVR1AURKAAURKB | |
| SCHEMBL5096947 | 0.84 | ACVR1 (0.62) | ABL1BCRACVR1AURKAAURKB | |
| SCHEMBL4763228 | 0.84 | ACVR1 (0.62) | ABL1BCRACVR1AURKAAURKB | |
| SCHEMBL4629853 | 0.83 | ABL1 (0.55) | ABL1BCRACVR1AURKAAURKB | |
| SCHEMBL5094718 | 0.83 | ACVR1 (0.62) | ABL1BCRACVR1AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | claimed |
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | AURKA, AURKC, PLK1 | ABL1 55/4885BCR 1018/4885ACVR1 1609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.