Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.62 |
| ▸ | BCR | P11274 | 1/20 | 0.62 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 4/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.46 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.46 |
| ▸ | ABL2 | P42684 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5097241 | 0.89 | ABL1 (0.57) | ABL1BCRACVR1JAK2JAK3 | |
| SCHEMBL4762065 | 0.87 | ABL1 (0.57) | ABL1BCRACVR1JAK2JAK3 | |
| SCHEMBL4629800 | 0.87 | ABL1 (0.57) | ABL1BCRACVR1JAK2JAK3 | |
| SCHEMBL5094548 | 0.87 | ABL1 (0.57) | ABL1BCRACVR1JAK2JAK3 | |
| SCHEMBL4629324 | 0.86 | ABL1 (0.56) | ABL1BCRACVR1JAK2JAK3 | |
| SCHEMBL5103208 | 0.86 | ABL1 (0.55) | ABL1BCRACVR1JAK2JAK3 | |
| SCHEMBL5103247 | 0.83 | ACVR1 (0.69) | ABL1BCRACVR1JAK2JAK3 | |
| SCHEMBL4629817 | 0.83 | ABL1 (0.54) | ABL1BCRACVR1JAK2JAK3 | |
| SCHEMBL5103286 | 0.80 | ABL1 (0.55) | ABL1BCRACVR1JAK2JAK3 | |
| SCHEMBL5090869 | 0.80 | ABL1 (0.57) | ABL1BCRACVR1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | AURKA, AURKC, PLK1 | ABL1 55/4885BCR 1018/4885ACVR1 1609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.