Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 20/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 19/20 | 1.00 |
| ▸ | DRD2 | P14416 | 6/20 | 0.75 |
| ▸ | HRH1 | P35367 | 4/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.72 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.72 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.72 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.72 |
| ▸ | HTR1D | P28221 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5111233 | 0.87 | DRD3 (0.77) | DRD3KCNH2DRD2HRH1CHRM2 | |
| SCHEMBL5105103 | 0.86 | DRD3 (1.00) | DRD3KCNH2DRD2HRH1CHRM2 | |
| SCHEMBL5104634 | 0.85 | DRD3 (0.81) | DRD3KCNH2DRD2HRH1CHRM2 | |
| SCHEMBL5105002 | 0.85 | DRD3 (0.75) | DRD3KCNH2DRD2HRH1CHRM2 | |
| SCHEMBL2287102 | 0.84 | DRD3 (1.00) | DRD3KCNH2DRD2HRH1CHRM2 | |
| Hydrochloric Acid SCHEMBL2363828 | 0.83 | DRD3 (0.98) | DRD3KCNH2DRD2HRH1CHRM2 | |
| SCHEMBL2316059 | 0.82 | DRD3 (1.00) | DRD3KCNH2HRH1 | |
| SCHEMBL4765674 | 0.82 | DRD3 (0.73) | DRD3KCNH2DRD2 | |
| SCHEMBL4773242 | 0.82 | DRD3 (0.75) | DRD3KCNH2DRD2 | |
| SCHEMBL2307625 | 0.81 | DRD3 (1.00) | DRD3KCNH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429579-B2 | Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents) | SMITHKLINE BEECHAM, PLC (GB) | 2008-09-30 | — | — | US | claimed |
| US-7429579-B2 | Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents) | SMITHKLINE BEECHAM, PLC (GB) | 2008-09-30 | — | — | US | disclosed |