Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 15/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5105270 | 1.00 | SYK (0.57) | SYKALKEGFRBTKBRD4 | |
| SCHEMBL5098856 | 0.92 | EGFR (0.52) | SYKALKEGFRBTK | |
| SCHEMBL5098852 | 0.92 | EGFR (0.52) | SYKALKEGFRBTK | |
| SCHEMBL5098701 | 0.91 | EGFR (0.51) | SYKALKEGFRBTKBRD4 | |
| SCHEMBL5098694 | 0.91 | EGFR (0.51) | SYKALKEGFRBTKBRD4 | |
| SCHEMBL5105150 | 0.90 | ALK (0.55) | SYKALKEGFRBTKBRD4 | |
| SCHEMBL5105153 | 0.90 | ALK (0.55) | SYKALKEGFRBTKBRD4 | |
| SCHEMBL5104865 | 0.88 | SYK (0.60) | SYKEGFRBTK | |
| SCHEMBL5104870 | 0.88 | SYK (0.60) | SYKEGFRBTK | |
| SCHEMBL2102260 | 0.85 | SYK (0.75) | SYKALKBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7452879-B2 | N4-(1-tert-Butoxycarbonylazetidin-3-yl)-5-fluoro-N2-(4-morpholinophenyl)-2,4-pyrimidinediamine; signal transduction cascade inhibitor; Fc receptors for IgE (\"Fc epsilon RI\") and IgG (\"Fc gamma RI\") antagonist; autoimmune diseases, antiinflammatory agent; rheumatoid arthritis, multiple sclerosis | RIGEL PHARMACEUTICALS, INC. (US) | 2008-11-18 | — | — | US | claimed |