Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.53 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5118969 | 0.88 | PDE5A (0.71) | PDE5AKDM4EALDH1A1MAPTPKM | |
| SCHEMBL5110749 | 0.83 | PDE5A (0.74) | PDE5APTGER1CASP3KMT2ASENP8 | |
| SCHEMBL5118966 | 0.82 | PDE5A (0.61) | PDE5AKDM4EALDH1A1MAPTNPC1 | |
| SCHEMBL5105687 | 0.81 | PDE5A (0.55) | PDE5AKDM4EALDH1A1MAPTPKM | |
| SCHEMBL5104788 | 0.77 | PDE5A (0.72) | PDE5ATDP1KDM4EALDH1A1MAPT | |
| SCHEMBL3081769 | 0.76 | PDE5A (0.76) | PDE5AKDM4EALDH1A1MAPTNPC1 | |
| SCHEMBL5110534 | 0.76 | PDE5A (0.67) | PDE5AKMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL5138807 | 0.75 | PDE5A (0.70) | PDE5AKDM4EALDH1A1MAPTNPC1 | |
| SCHEMBL5140293 | 0.73 | PDE5A (0.60) | PDE5AKMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL16267521 | 0.72 | PDE5A (0.71) | PDE5AKMT2AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378532-B2 | Fused pyrazolyl compound | YUNG SHIN PHARMACEUTICAL IND. CO., LTD. (TW) | 2008-05-27 | — | — | US | claimed |
| EP-1586572-A1 | Fused pyrazolyls as anti-cancer drugs | Yung Shin Pharm. Ind. Co. Ltd. (TW) | 2005-10-19 | — | — | EP | claimed |
| US-20050215612-A1 | Novel fused pyrazolyl compound | YUNG SHIN PHARMACEUTICAL IND. CO., LTD. (TW) | 2005-09-29 | — | — | US | claimed |
| US-7378532-B2 | Fused pyrazolyl compound | YUNG SHIN PHARMACEUTICAL IND. CO., LTD. (TW) | 2008-05-27 | — | — | US | disclosed |
| EP-1586572-A1 | Fused pyrazolyls as anti-cancer drugs | Yung Shin Pharm. Ind. Co. Ltd. (TW) | 2005-10-19 | — | — | EP | disclosed |
| US-20050215612-A1 | Novel fused pyrazolyl compound | YUNG SHIN PHARMACEUTICAL IND. CO., LTD. (TW) | 2005-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215612-A1 | Novel fused pyrazolyl compound | AR, ARL1, NR5A2 | PDE5A 2742/4885PTGER1 221/4885CASP3 2918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.