Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.69 |
| ▸ | MEN1 | O00255 | 6/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CRHBP | P24387 | 2/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5120588 | 0.93 | TDP1 (0.60) | KMT2AMEN1TDP1HPGDCYP1A2 | |
| SCHEMBL5117637 | 0.93 | TDP1 (0.60) | KMT2AMEN1TDP1HPGDCYP1A2 | |
| SCHEMBL5119125 | 0.91 | TDP1 (0.65) | KMT2AMEN1TDP1HPGDCYP1A2 | |
| SCHEMBL5112148 | 0.91 | TDP1 (0.64) | KMT2AMEN1TDP1HPGDCYP1A2 | |
| SCHEMBL27725402 | 0.89 | TDP1 (0.56) | KMT2AMEN1TDP1HPGDCYP1A2 | |
| SCHEMBL5115225 | 0.89 | TDP1 (0.56) | KMT2AMEN1TDP1HPGDCYP1A2 | |
| SCHEMBL5111974 | 0.88 | TDP1 (0.70) | KMT2AMEN1TDP1HPGDCYP1A2 | |
| SCHEMBL5119920 | 0.87 | TDP1 (0.66) | KMT2AMEN1TDP1HPGDCYP1A2 | |
| SCHEMBL5110692 | 0.87 | TDP1 (0.54) | KMT2AMEN1TDP1HPGDCYP1A2 | |
| SCHEMBL5119450 | 0.87 | TDP1 (0.54) | KMT2AMEN1TDP1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | BAYER HEALTHCARE AG (DE) | 2008-08-14 | — | — | US | disclosed |
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | BAYER HEALTHCARE AG (DE) | 2008-08-14 | — | — | US | disclosed |
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | BAYER HEALTHCARE AG (DE) | 2008-08-14 | — | — | US | disclosed |
| CN-101175731-A | Pyrimidine carboxylic acid derivatives and uses thereof | BAYER HEALTHCARE AG (DE) | 2008-05-07 | — | — | CN | disclosed |
| EP-1866289-A1 | PYRIMIDINE CARBOXYLIC ACID DERIVATIVES AND USE THEREOF | Bayer HealthCare AG (DE) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006097220-A1 | PYRIMIDINE CARBOXYLIC ACID DERIVATIVES AND USE THEREOF | BAYER HEALTHCARE AG (DE) | 2006-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194598-A1 | Pyrimidine Carboxylic Acid Derivatives and Use Thereof | DPYD, TYMP, TYMS | KMT2A 3441/4885MEN1 4226/4885TDP1 273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.