Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 20/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 17/20 | 0.52 |
| ▸ | HRH1 | P35367 | 8/20 | 0.52 |
| ▸ | DRD2 | P14416 | 4/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5101887 | 0.89 | DRD3 (0.53) | DRD3KCNH2HRH1DRD2CHRM2 | |
| SCHEMBL4773739 | 0.87 | DRD3 (0.68) | DRD3KCNH2HRH1DRD2CHRM2 | |
| SCHEMBL4839391 | 0.85 | DRD3 (0.63) | DRD3KCNH2HRH1DRD2 | |
| SCHEMBL4836950 | 0.84 | DRD3 (0.53) | DRD3KCNH2HRH1DRD2CHRM2 | |
| SCHEMBL4773705 | 0.83 | DRD3 (0.50) | DRD3KCNH2HRH1DRD2CHRM2 | |
| SCHEMBL4768113 | 0.83 | DRD3 (0.54) | DRD3KCNH2HRH1DRD2 | |
| SCHEMBL4767819 | 0.82 | DRD3 (0.64) | DRD3KCNH2HRH1DRD2 | |
| SCHEMBL4763624 | 0.82 | DRD3 (0.51) | DRD3KCNH2DRD2 | |
| SCHEMBL5111671 | 0.80 | DRD3 (0.64) | DRD3KCNH2DRD2 | |
| SCHEMBL4770301 | 0.80 | DRD3 (0.55) | DRD3KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429579-B2 | Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents) | SMITHKLINE BEECHAM, PLC (GB) | 2008-09-30 | — | — | US | claimed |
| US-7429579-B2 | Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents) | SMITHKLINE BEECHAM, PLC (GB) | 2008-09-30 | — | — | US | disclosed |