Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 20/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 18/20 | 0.49 |
| ▸ | DRD2 | P14416 | 11/20 | 0.49 |
| ▸ | HRH1 | P35367 | 7/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5105174 | 0.93 | DRD3 (0.50) | DRD3KCNH2DRD2HRH1CHRM2 | |
| SCHEMBL5111009 | 0.88 | DRD3 (0.51) | DRD3KCNH2DRD2HRH1CHRM2 | |
| SCHEMBL5104991 | 0.86 | DRD3 (0.61) | DRD3KCNH2DRD2 | |
| SCHEMBL5105683 | 0.85 | DRD3 (0.51) | DRD3KCNH2DRD2HRH1CHRM2 | |
| SCHEMBL5101623 | 0.85 | DRD3 (0.68) | DRD3KCNH2DRD2 | |
| SCHEMBL4768628 | 0.83 | DRD3 (0.69) | DRD3KCNH2DRD2HRH1CHRM2 | |
| SCHEMBL5098345 | 0.82 | NPC1 (0.58) | DRD3KCNH2DRD2 | |
| SCHEMBL5102080 | 0.82 | DRD3 (0.67) | DRD3KCNH2DRD2HRH1CHRM2 | |
| SCHEMBL5098279 | 0.82 | DRD3 (0.49) | DRD3KCNH2DRD2HRH1CHRM2 | |
| SCHEMBL5104990 | 0.82 | DRD3 (0.54) | DRD3KCNH2DRD2HRH1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429579-B2 | Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents) | SMITHKLINE BEECHAM, PLC (GB) | 2008-09-30 | — | — | US | disclosed |