Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 11/20 | 0.46 |
| ▸ | AURKA | O14965 | 10/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.46 |
| ▸ | CDK4 | P11802 | 9/20 | 0.43 |
| ▸ | CCND1 | P24385 | 9/20 | 0.43 |
| ▸ | CCND3 | P30281 | 9/20 | 0.43 |
| ▸ | CCND2 | P30279 | 8/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.42 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.42 |
| ▸ | NUAK2 | Q9H093 | 1/20 | 0.42 |
| ▸ | MARK1 | Q9P0L2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5119187 | 1.00 | CDK1 (0.46) | CDK1AURKAAURKBCDK4CCND1 | |
| SCHEMBL5128100 | 0.97 | CDK1 (0.42) | CDK1AURKAAURKBCDK4CCND1 | |
| SCHEMBL5120764 | 0.95 | AURKA (0.40) | CDK1AURKAAURKBCDK4CCND1 | |
| SCHEMBL5126819 | 0.91 | CDK4 (0.41) | CDK1AURKAAURKBCDK4CCND1 | |
| SCHEMBL5120113 | 0.91 | CDK1 (0.51) | CDK1AURKAAURKBCDK4CCND1 | |
| SCHEMBL5112908 | 0.91 | CDK1 (0.51) | CDK1AURKAAURKBCDK4CCND1 | |
| SCHEMBL3339263 | 0.90 | CDK4 (0.44) | CDK1CDK4CCND1CCND3CCND2 | |
| SCHEMBL5121339 | 0.89 | CDK1 (0.44) | CDK1AURKAAURKBCDK4CCND1 | |
| SCHEMBL5120148 | 0.88 | CDK1 (0.49) | CDK1AURKAAURKBCDK4CCND1 | |
| SCHEMBL5126997 | 0.86 | AURKA (0.47) | CDK1AURKAAURKBCDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255162-A1 | Pyrrolyl Substituted Pyrido[2,3-D]Pyrimidin-7-Ones and Derivatives Thereof as Therapeutic Agents | WARNER-LAMBERT COMPANY LLC | 2008-10-16 | — | — | US | disclosed |
| EP-1749004-B1 | PYRROLYL SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7-ONES AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS | WARNER LAMBERT CO (US) | 2007-09-19 | — | — | EP | disclosed |
| EP-1749004-A1 | PYRROLYL SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7-ONES AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS | Warner-Lambert Company LLC (US) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005105801-A1 | PYRROLYL SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7-ONES AND DERIVATIVES THEREOF AS THERAPEUTIC AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255162-A1 | Pyrrolyl Substituted Pyrido[2,3-D]Pyrimidin-7-Ones and Derivatives Thereof as Therapeutic Agents | TYMS, DPYD, TYMP | CDK1 252/4885AURKA 2195/4885AURKB 1542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.