Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 12/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | PAK4 | O96013 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | SGK1 | O00141 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4777744 | 0.91 | LRRK2 (0.44) | PTK2LRRK2AURKAJAK2PAK4 | |
| SCHEMBL4843165 | 0.90 | LRRK2 (0.54) | PTK2LRRK2AURKAJAK2PAK4 | |
| SCHEMBL5114610 | 0.89 | PTK2 (0.46) | PTK2LRRK2AURKAJAK2PAK4 | |
| SCHEMBL5122621 | 0.88 | KMT2A (0.43) | PTK2LRRK2AURKAJAK2PAK4 | |
| SCHEMBL5124617 | 0.88 | PTK2 (0.50) | PTK2LRRK2AURKAJAK2PAK4 | |
| SCHEMBL5121866 | 0.87 | PTK2 (0.42) | PTK2LRRK2AURKAJAK2PAK4 | |
| SCHEMBL5114747 | 0.86 | PTK2 (0.59) | PTK2LRRK2AURKAJAK2PAK4 | |
| SCHEMBL14547930 | 0.83 | PTK2 (0.43) | PTK2LRRK2AURKAJAK2PAK4 | |
| SCHEMBL5121869 | 0.82 | LRRK2 (0.36) | PTK2LRRK2AURKAJAK2PAK4 | |
| SCHEMBL14547961 | 0.81 | SYK (0.35) | PTK2LRRK2AURKAJAK2PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080004295-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-01-03 | — | — | US | disclosed |
| US-20080004295-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-01-03 | — | — | US | disclosed |
| US-20080004295-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-01-03 | — | — | US | disclosed |
| WO-2007042298-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007042299-A1 | PYRROLOPYRIMIDINE DERIVATIVES AS SYK INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004295-A1 | NOVEL COMPOUNDS | SYK, BTK, LCK | PTK2 219/4885LRRK2 2483/4885AURKA 1260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.