⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL336094 | 1.00 | — | — | |
| SCHEMBL1524401 | 0.81 | HPGD (0.31) | — | |
| SCHEMBL1524477 | 0.81 | HPGD (0.31) | — | |
| SCHEMBL1524402 | 0.81 | HPGD (0.31) | — | |
| SCHEMBL7611471 | 0.79 | TSHR (0.32) | — | |
| SCHEMBL15092008 | 0.73 | — | — | |
| SCHEMBL9181461 | 0.73 | — | — | |
| SCHEMBL9181457 | 0.73 | — | — | |
| SCHEMBL9403572 | 0.73 | — | — | |
| SCHEMBL9181474 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-63112558-A | — | — | None | — | — | JP | disclosed |
| US-7329654-B2 | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-02-12 | — | — | US | disclosed |
| US-7105679-B2 | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators | KANOJIA RAMESH M | 2006-09-12 | — | — | US | disclosed |
| US-7037989-B2 | Copolymers of ethylene and/or α-olefins and vicinally disubstituted olefins | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2006-05-02 | — | — | US | disclosed |
| EP-1467998-B1 | TETRACYCLIC HETEROCOMPOUNDS AS ESTROGEN RECEPTOR MODULATORS | ORTHO MCNEIL PHARM INC (US) | 2006-03-29 | — | — | EP | disclosed |
| US-6951942-B2 | Glucocorticoid-selective anti-inflammatory agents | ABBOTT LABORATORIES (US) | 2005-10-04 | — | — | US | disclosed |
| EP-1569939-A1 | NOVEL HETEROATOM CONTAINING TETRACYCLIC DERIVATIVES AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2005-09-07 | — | — | EP | disclosed |
| US-20040259915-A1 | Novel heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators | KANOJIA RAMESH M (US) | 2004-12-23 | — | — | US | disclosed |
| WO-2004106394-A1 | COPOLYMERS OF ETHYLENE AND/OR α-OLEFINS AND VICINALLY DISUBSTITUTED OLEFINS | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2004-12-09 | — | — | WO | disclosed |
| US-20040242814-A1 | COPOLYMERS OF ETHYLENE AND/OR ALPHA-OLEFINS AND VICINALLY DISUBSTITUTED OLEFINS | EXXONMOBIL CHEMICAL PATENTS INC. | 2004-12-02 | — | — | US | disclosed |
| WO-2003027117-A1 | A PROCESS FOR THE PREPARATION OF 5-(SUBSTITUTED)-10-METHOXY-2,2,4-TRIMETHYL-2,5-DIHYDRO-1H-CHROMENO[3,4-F]QUINOLINES AND DERIVATIVES THEREOF | ABBOTT LABORATORIES (US) | 2003-04-03 | — | — | WO | disclosed |
| US-6518430-B1 | The present invention relates to an efficient process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5- dihydro-1H-chromeno(3,4-f)quinolines. | ABBOTT LABORATORIES | 2003-02-11 | — | — | US | disclosed |
| US-6506766-B1 | A pharmaceutical composition for use in treating inflammation, immune, autoimmune, and inflammatory diseases in a mammal by selectively modulating the activation, repression, agonism, and antagonism effects of the mammal's glucocorticoid | ABBOTT LABORATORIES | 2003-01-14 | — | — | US | disclosed |
| EP-1053239-B1 | GLUCOCORTICOID-SELECTIVE ANTI-INFLAMMATORY AGENTS | ABBOTT LAB (US) | 2003-01-08 | — | — | EP | disclosed |
| WO-2002002565-A2 | GLUCOCORTIOCOID-SELECTIVE ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 2002-01-10 | — | — | WO | disclosed |
| JP-S63112558-A | PRODUCTION OF 4-(1-SUBSTITUTED ALLYL)-2-AZETIDINONE COMPOUND | FUJISAWA PHARMACEUT CO LTD | 1988-05-17 | — | — | JP | disclosed |
| US-4454243-A | REACTING LITHIUM AND AN ALKENE USING A TRANSITION OR ALKALI METAL COMPLEX | STUDIENGESELLSCHAFT KOHLE MBH (DE) | 1984-06-12 | — | — | US | disclosed |
| EP-0015541-B1 | PROCESS FOR THE PREPARATION OF ORGANOLITHIUM COMPOUNDS BESIDES LITHIUM HYDRIDE; CATALYSTS | Studiengesellschaft Kohle mbH (DE) | 1984-03-07 | — | — | EP | disclosed |
| US-4354982-A | Production of organolithium compounds and lithium hydride | STUDIENGESELLSCHAFT KOHLE M.B.H. (DE) | 1982-10-19 | — | — | US | disclosed |
| EP-0015541-A2 | Process for the preparation of organolithium compounds besides lithium hydride; catalysts | Studiengesellschaft Kohle mbH (DE) | 1980-09-17 | — | — | EP | disclosed |