Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 15/20 | 0.49 |
| ▸ | GSK3A | P49840 | 13/20 | 0.49 |
| ▸ | SRC | P12931 | 10/20 | 0.49 |
| ▸ | SYK | P43405 | 10/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14276141 | 0.92 | MAPK14 (0.50) | MAPK14GSK3ASRCSYKCYP3A4 | |
| SCHEMBL14276173 | 0.91 | MAPK14 (0.49) | BRAFMAPK14GSK3ASRCSYK | |
| SCHEMBL14276191 | 0.90 | MAPK14 (0.47) | BRAFMAPK14GSK3ASRCSYK | |
| SCHEMBL5681489 | 0.90 | GSK3A (0.52) | MAPK14GSK3ASRCSYKCYP3A4 | |
| SCHEMBL14276144 | 0.90 | MAPK14 (0.51) | MAPK14GSK3ASRCSYKCYP3A4 | |
| SCHEMBL14276140 | 0.89 | GSK3A (0.51) | MAPK14GSK3ASRCSYKCYP3A4 | |
| SCHEMBL14276179 | 0.89 | MAPK14 (0.50) | MAPK14GSK3ASRCSYKCYP3A4 | |
| SCHEMBL14276256 | 0.88 | MAPK14 (0.49) | MAPK14GSK3ASRCSYKCYP3A4 | |
| SCHEMBL14276170 | 0.88 | MAPK14 (0.49) | MAPK14GSK3ASRCSYKCYP3A4 | |
| SCHEMBL5111500 | 0.86 | GSK3A (0.49) | MAPK14GSK3ASRCSYKCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-7335657-B2 | Cytokine inhibitors | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2008-02-26 | — | — | US | disclosed |
| US-7078419-B2 | N-aryl-7-(pyridin-4yl-methyl-, oxy-, thio-or amino-)indole-2-carbonamide derivatives, e.g., 7-(2,6-Dimethyl-pyridin-4-yloxy)-1H-indole-2-carboxylic acid (5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenyl)-amide; treating chronic inflammatory diseases and anticoagulant or fibrinolytic therapy | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-07-18 | — | — | US | disclosed |