Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 3/20 | 1.00 |
| ▸ | CDK2 | P24941 | 3/20 | 1.00 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 1.00 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 1.00 |
| ▸ | PDPK1 | O15530 | 1/20 | 1.00 |
| ▸ | ATR | Q13535 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5116173 | 0.99 | CDK1 (0.97) | CDK1CDK2MKNK1MKNK2PDPK1 | |
| SCHEMBL2681945 | 0.91 | CDK1 (0.83) | CDK1CDK2MKNK1MKNK2PDPK1 | |
| SCHEMBL2681176 | 0.89 | CDK1 (0.79) | CDK1CDK2MKNK1MKNK2PDPK1 | |
| SCHEMBL2680638 | 0.88 | CDK1 (0.79) | CDK1CDK2MKNK1MKNK2PDPK1 | |
| SCHEMBL2682567 | 0.88 | CDK1 (0.79) | CDK1CDK2MKNK1MKNK2PDPK1 | |
| SCHEMBL5118616 | 0.87 | CDK1 (0.77) | CDK1CDK2MKNK1MKNK2PDPK1 | |
| Hydrochloric Acid SCHEMBL5119587 | 0.86 | CDK1 (0.75) | CDK1CDK2MKNK1MKNK2PDPK1 | |
| SCHEMBL2682556 | 0.86 | CDK1 (0.75) | CDK1CDK2MKNK1MKNK2PDPK1 | |
| SCHEMBL2682848 | 0.85 | CDK1 (0.73) | CDK1CDK2MKNK1MKNK2PDPK1 | |
| SCHEMBL5120432 | 0.84 | CDK1 (0.72) | CDK1CDK2MKNK1MKNK2PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7329678-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-12 | — | — | US | claimed |
| EP-1590339-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-07-25 | — | — | EP | claimed |
| US-20060148854-A1 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2006-07-06 | — | — | US | claimed |
| JP-2006516626-A | — | — | 2006-07-06 | — | — | JP | claimed |
| EP-1590339-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2005-11-02 | — | — | EP | claimed |
| WO-2004069160-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-08-19 | — | — | WO | claimed |
| US-7329678-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329678-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-12 | — | — | US | disclosed |
| US-7329678-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-12 | — | — | US | disclosed |
| EP-1590339-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-07-25 | — | — | EP | disclosed |
| US-20060148854-A1 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2006-07-06 | — | — | US | disclosed |
| EP-1590339-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2005-11-02 | — | — | EP | disclosed |
| WO-2004069160-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-08-19 | — | — | WO | disclosed |
| WO-2004069160-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-08-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148854-A1 | Chemical compounds | SGK1, SGK2, SGK3 | CDK1 356/4885CDK2 667/4885MKNK1 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.