Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 11/20 | 0.57 |
| ▸ | BRAF | P15056 | 9/20 | 0.57 |
| ▸ | KDR | P35968 | 6/20 | 0.50 |
| ▸ | RET | P07949 | 4/20 | 0.50 |
| ▸ | ABL1 | P00519 | 3/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.46 |
| ▸ | PLK4 | O00444 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | FYN | P06241 | 2/20 | 0.46 |
| ▸ | LYN | P07948 | 2/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.46 |
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | FRK | P42685 | 2/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3989166 | 0.91 | RAF1 (0.70) | RAF1BRAFKDRRETABL1 | |
| SCHEMBL14266592 | 0.90 | BRAF (0.51) | RAF1BRAFKDRRETABL1 | |
| SCHEMBL14266541 | 0.90 | RAF1 (0.56) | RAF1BRAFKDRRETABL1 | |
| SCHEMBL3985600 | 0.89 | BRAF (0.49) | RAF1BRAFKDRRETABL1 | |
| SCHEMBL14266605 | 0.88 | BRAF (0.55) | RAF1BRAFKDRRETABL1 | |
| SCHEMBL14273368 | 0.87 | TRPV1 (0.45) | RAF1BRAFCA7CDK8CA9 | |
| SCHEMBL3989035 | 0.87 | BRAF (0.49) | RAF1BRAFKDRRETABL1 | |
| SCHEMBL3984330 | 0.87 | KDR (0.67) | RAF1BRAFKDRRETABL1 | |
| SCHEMBL3986272 | 0.85 | NR3C2 (0.45) | RAF1BRAFKDRMAPK14CA7 | |
| SCHEMBL3983677 | 0.85 | RAF1 (0.58) | RAF1BRAFKDRRETABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080064729-A1 | Phenethylamide derivatives with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-03-13 | — | — | US | disclosed |
| US-20080064729-A1 | Phenethylamide derivatives with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-03-13 | — | — | US | disclosed |
| US-20080064729-A1 | Phenethylamide derivatives with kinase inhibitory activity | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-03-13 | — | — | US | disclosed |
| WO-2008030448-A1 | PHENETHYLAMIDE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064729-A1 | Phenethylamide derivatives with kinase inhibitory activity | MAP4K5, MAP3K5, MAP4K2 | RAF1 251/4885BRAF 242/4885KDR 1073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.