Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UGT1A1 | P22309 | 2/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.67 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.67 |
| ▸ | PSEN1 | P49768 | 18/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 18/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 18/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 18/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 18/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 18/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL514027 | 0.88 | UGT1A1 (0.68) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 | |
| SCHEMBL1227770 | 0.84 | UGT1A1 (0.72) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 | |
| SCHEMBL513523 | 0.83 | UGT1A1 (0.63) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 | |
| SCHEMBL511902 | 0.83 | UGT1A1 (0.67) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 | |
| SCHEMBL513955 | 0.82 | UGT1A1 (0.62) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 | |
| SCHEMBL512594 | 0.82 | UGT1A1 (0.61) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 | |
| SCHEMBL1226847 | 0.81 | KCNH2 (0.67) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 | |
| SCHEMBL137802 | 0.80 | UGT1A1 (0.64) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 | |
| SCHEMBL10258896 | 0.80 | UGT1A1 (1.00) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 | |
| SCHEMBL9285182 | 0.80 | UGT1A1 (1.00) | UGT1A1KCNH2SLCO1B1PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637525-B2 | Compounds for the reduction of beta-amyloid production | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-01-28 | — | — | US | claimed |
| US-20120028994-A1 | COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY | 2012-02-02 | — | — | US | claimed |
| US-8637525-B2 | Compounds for the reduction of beta-amyloid production | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-01-28 | — | — | US | disclosed |
| US-8637525-B2 | Compounds for the reduction of beta-amyloid production | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-01-28 | — | — | US | disclosed |
| US-8637525-B2 | Compounds for the reduction of beta-amyloid production | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-01-28 | — | — | US | disclosed |
| US-20120028994-A1 | COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY | 2012-02-02 | — | — | US | disclosed |
| US-20120028994-A1 | COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY | 2012-02-02 | — | — | US | disclosed |
| US-20120028994-A1 | COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | BRISTOL-MYERS SQUIBB COMPANY | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028994-A1 | COMPOUNDS FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION | APP, BACE1, IAPP | UGT1A1 3409/4885KCNH2 4707/4885SLCO1B1 3830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.