Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.45 |
| ▸ | IGF1R | P08069 | 3/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.45 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4224285 | 0.79 | CA12 (0.51) | KDM4EALDH1A1HPGDKMT2ALMNA | |
| SCHEMBL6973438 | 0.73 | HSD17B10 (0.66) | KDM4EALDH1A1HPGDKMT2ALMNA | |
| SCHEMBL11346077 | 0.73 | ATM (0.57) | KDM4EALDH1A1HPGDKMT2ALMNA | |
| SCHEMBL5117114 | 0.72 | HRH3 (0.50) | ALDH1A1HPGDKMT2ALMNAESR2 | |
| SCHEMBL1663516 | 0.72 | CA9 (0.55) | KDM4EALDH1A1HPGDKMT2ALMNA | |
| SCHEMBL11281609 | 0.71 | NPC1 (0.48) | KDM4EALDH1A1HPGDKMT2AATM | |
| SCHEMBL14176442 | 0.71 | PDE3B (0.45) | ALDH1A1KMT2ALMNAESR2ESR1 | |
| SCHEMBL5120987 | 0.71 | PDE3B (0.45) | ALDH1A1KMT2ALMNAHSD17B10SMN1; SMN2 | |
| SCHEMBL14123260 | 0.71 | ATM (0.63) | KDM4EALDH1A1HPGDKMT2ALMNA | |
| SCHEMBL29588320 | 0.70 | ABCG2 (0.60) | KDM4EALDH1A1HPGDKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7381730-B2 | 3-arylquinazoline derivatives as selective estrogen receptor beta modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-03 | — | — | US | disclosed |
| US-20030220227-A1 | 3-Arylquinazoline derivatives as selective estrogen receptor beta modulators | BRISTOL-MYERS SQUIBB COMPANY | 2003-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030220227-A1 | 3-Arylquinazoline derivatives as selective estrogen receptor beta modulators | ESR2, ESRRA, ESRRG | KDM4E 2521/4885ALDH1A1 3264/4885HPGD 2229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.