Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.42 |
| ▸ | PDE4A | P27815 | 3/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3674705 | 0.82 | PDE4B (0.69) | PDE4BMCL1 | |
| SCHEMBL3676882 | 0.72 | PDE4B (0.76) | PDE4BPDE4D | |
| SCHEMBL729197 | 0.71 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3683301 | 0.68 | PDE4B (0.70) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3673103 | 0.68 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3678587 | 0.68 | PDE4B (1.00) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3678464 | 0.68 | PDE4B (0.86) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3681574 | 0.68 | PDE4B (0.88) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3676425 | 0.67 | PDE4B (0.70) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3678716 | 0.67 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008006051-A2 | BICYCLIC HETEROARYL INHIBITORS OF PDE4 | GOVEK STEVEN P (US) | 2008-01-10 | — | — | WO | disclosed |