Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.79 |
| ▸ | RAF1 | P04049 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3041272 | 0.88 | BRAF (0.72) | BRAFRAF1 | |
| SCHEMBL3042504 | 0.87 | BRAF (0.78) | BRAFRAF1 | |
| SCHEMBL3034254 | 0.84 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL4735381 | 0.82 | BRAF (0.78) | BRAFRAF1 | |
| SCHEMBL3029301 | 0.80 | BRAF (0.73) | BRAFRAF1 | |
| SCHEMBL3044655 | 0.77 | BRAF (0.73) | BRAFRAF1 | |
| SCHEMBL3037055 | 0.75 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL4747175 | 0.75 | BRAF (0.72) | BRAFRAF1 | |
| SCHEMBL3033956 | 0.73 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL5129995 | 0.73 | BRAF (0.77) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008020203-A1 | PYRIDINYLQUINAZ0LINAMINE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | WO | disclosed |