Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 4/20 | 0.82 |
| ▸ | INSR | P06213 | 3/20 | 0.82 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.67 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.67 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.65 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.64 |
| ▸ | GSK3A | P49840 | 3/20 | 0.63 |
| ▸ | GSK3B | P49841 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5128536 | 1.00 | IGF1R (0.82) | IGF1RINSRSIRT2SIRT1SIRT5 | |
| SCHEMBL14277837 | 1.00 | IGF1R (0.82) | IGF1RINSRSIRT2SIRT1SIRT5 | |
| SCHEMBL623774 | 0.90 | IGF1R (1.00) | IGF1RINSRPIK3CGPTP4A3GSK3A | |
| SCHEMBL623775 | 0.90 | IGF1R (1.00) | IGF1RINSRPIK3CGPTP4A3GSK3A | |
| SCHEMBL623776 | 0.90 | IGF1R (1.00) | IGF1RINSRPIK3CGPTP4A3GSK3A | |
| SCHEMBL3890812 | 0.81 | IGF1R (0.74) | IGF1RINSRPIK3CGPTP4A3GSK3A | |
| SCHEMBL3890807 | 0.81 | IGF1R (0.74) | IGF1RINSRPIK3CGPTP4A3GSK3A | |
| SCHEMBL13236142 | 0.81 | IGF1R (0.74) | IGF1RINSRPIK3CGPTP4A3GSK3A | |
| SCHEMBL6090652 | 0.81 | IGF1R (0.74) | IGF1RINSRPIK3CGPTP4A3GSK3A | |
| SCHEMBL622800 | 0.81 | PIK3CG (0.80) | IGF1RINSRPIK3CGPTP4A3GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080051445-A1 | 2-Thioxothiazolidin-4-one compounds and compositions as antimicrobial and antimalarial agents targeting enoyl-ACP reductase of type II fatty acid synthesis pathway and other cell growth pathways | NATIONAL INSTITUTE OF IMMUNOLOGY. | 2008-02-28 | — | — | US | disclosed |
| EP-1834642-A2 | 2-thioxothiazolidin-4-one compounds and compositions as antimicrobial and antimalarial agents targeting enoyl-ACP reductase of type II fatty acid synthesis pathway and other cell growth pathways | National Institute of Immunology (IN) | 2007-09-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051445-A1 | 2-Thioxothiazolidin-4-one compounds and compositions as antimicrobial and antimalarial agents targeting enoyl-ACP reductase of type II fatty acid synthesis pathway and other cell growth pathways | FASN, FADS2, TECR | IGF1R 3557/4885INSR 2530/4885SIRT2 623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.