Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 11/20 | 0.54 |
| ▸ | HSP90AB1 | P08238 | 11/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSP90B1 | P14625 | 6/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5131902 | 0.87 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1HSP90B1MAPK1 | |
| SCHEMBL3124520 | 0.86 | ADORA2A (0.46) | HSP90AA1HSP90AB1HSP90B1MAPK1 | |
| SCHEMBL3122642 | 0.84 | ADORA2A (0.53) | HSP90AA1HSP90AB1HSP90B1MAPK1 | |
| SCHEMBL3124080 | 0.84 | HSP90B1 (0.44) | HSP90AA1HSP90AB1HSP90B1MAPK1 | |
| SCHEMBL3119617 | 0.82 | MAPK1 (0.42) | HSP90AA1HSP90AB1KMT2AHSP90B1MAPK1 | |
| SCHEMBL3121969 | 0.80 | ADORA2A (0.48) | HSP90AA1HSP90AB1KMT2AHSP90B1MAPK1 | |
| SCHEMBL3111452 | 0.79 | ADORA2A (0.45) | HSP90AA1HSP90AB1HSP90B1MAPK1 | |
| SCHEMBL5142342 | 0.78 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1HSP90B1MAPK1 | |
| SCHEMBL5035593 | 0.72 | HSP90AA1 (0.56) | HSP90AA1HSP90AB1HSP90B1HDAC3HDAC4 | |
| SCHEMBL5130186 | 0.72 | HSP90AB1 (0.56) | HSP90AA1HSP90AB1HSP90B1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962863-A2 | ORALLY ACTIVE PURINE-BASED INHIBITORS OF HEAT SHOCK PROTEIN 90 | Conforma Therapeutics Corporation (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007075572-A2 | ORALLY ACTIVE PURINE-BASED INHIBITORS OF HEAT SHOCK PROTEIN 90 | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| US-20070129334-A1 | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129334-A1 | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AA1 2/4885HSP90AB1 1/4885KMT2A 4440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.