Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 11/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.53 |
| ▸ | MT-CO1 | P00395 | 1/20 | 0.53 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | CA6 | P23280 | 2/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31429136 | 0.89 | PTGS1 (0.44) | PTGS1PTGS2MT-CO1MT-CO2POLB | |
| SCHEMBL8414651 | 0.81 | PTGS1 (0.55) | PTGS1PTGS2MT-CO1MT-CO2POLB | |
| SCHEMBL8417619 | 0.81 | PTGS1 (0.55) | PTGS1PTGS2MT-CO1MT-CO2POLB | |
| SCHEMBL8414650 | 0.81 | PTGS1 (0.55) | PTGS1PTGS2MT-CO1MT-CO2POLB | |
| SCHEMBL8414647 | 0.81 | PTGS1 (0.55) | PTGS1PTGS2MT-CO1MT-CO2POLB | |
| SCHEMBL8417618 | 0.81 | PTGS1 (0.55) | PTGS1PTGS2MT-CO1MT-CO2POLB | |
| SCHEMBL25698186 | 0.79 | PTGS1 (0.54) | PTGS1PTGS2MT-CO1MT-CO2POLB | |
| SCHEMBL25698182 | 0.79 | PTGS1 (0.54) | PTGS1PTGS2MT-CO1MT-CO2POLB | |
| SCHEMBL11591641 | 0.79 | PTGS1 (0.54) | PTGS1PTGS2MT-CO1MT-CO2POLB | |
| SCHEMBL19271011 | 0.78 | POLB (0.43) | POLBLMNAALOX12NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773780-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2008-01-09 | — | — | EP | claimed |
| EP-1773780-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006012227-A2 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-02 | — | — | WO | claimed |