Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.45 |
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KHK | P50053 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 3/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5131442 | 1.00 | IRAK4 (0.45) | IRAK4PIM1PIM2BRD4KDM4E | |
| Hydrochloric Acid SCHEMBL5132003 | 0.99 | IRAK4 (0.45) | IRAK4PIM1PIM2BRD4KDM4E | |
| Hydrochloric Acid SCHEMBL5132006 | 0.99 | IRAK4 (0.45) | IRAK4PIM1PIM2BRD4KDM4E | |
| SCHEMBL3956316 | 0.87 | KDM4E (0.46) | IRAK4PIM1PIM2KDM4EALDH1A1 | |
| SCHEMBL5132445 | 0.87 | IRAK4 (0.43) | IRAK4PIM1PIM2BRD4KHK | |
| SCHEMBL5132442 | 0.87 | IRAK4 (0.43) | IRAK4PIM1PIM2BRD4KHK | |
| SCHEMBL5128320 | 0.87 | IRAK4 (0.43) | IRAK4PIM1PIM2BRD4KDM4E | |
| Hydrochloric Acid SCHEMBL3962445 | 0.86 | KDM4E (0.45) | IRAK4PIM1PIM2KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL3961214 | 0.86 | IRAK4 (0.43) | IRAK4PIM1PIM2BRD4KHK | |
| Hydrochloric Acid SCHEMBL3961216 | 0.86 | IRAK4 (0.43) | IRAK4PIM1PIM2BRD4KHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194616-A1 | PYRIDOPYRIMIDINONE COMPOUNDS USEFUL IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-14 | — | — | US | claimed |
| US-20080194616-A1 | PYRIDOPYRIMIDINONE COMPOUNDS USEFUL IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194616-A1 | PYRIDOPYRIMIDINONE COMPOUNDS USEFUL IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | SCN1A, SCN3A, SCN1B | IRAK4 1483/4885PIM1 4321/4885PIM2 4345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.