Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN7A | Q01118 | 2/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL706122 | 0.85 | KCNH2 (0.50) | SCN7ASCN5ASCN2ASCN8AKCNH2 | |
| SCHEMBL923527 | 0.80 | KCNH2 (0.51) | KCNH2 | |
| SCHEMBL706674 | 0.79 | KCNH2 (0.45) | SCN7ASCN5ASCN2ASCN8AKCNH2 | |
| SCHEMBL4779522 | 0.78 | SCN7A (0.58) | SCN7ASCN5ASCN2ASCN8AKCNH2 | |
| SCHEMBL4777392 | 0.77 | KCNH2 (0.38) | KCNH2 | |
| SCHEMBL708368 | 0.76 | KCNH2 (0.56) | KCNH2CYP3A4CYP2D6 | |
| SCHEMBL12002208 | 0.75 | KCNH2 (0.55) | KCNH2CYP3A4CYP2D6 | |
| SCHEMBL4776915 | 0.75 | KCNH2 (0.47) | KCNH2 | |
| SCHEMBL922035 | 0.72 | KCNH2 (0.57) | KCNH2CYP3A4CYP2D6 | |
| SCHEMBL708597 | 0.71 | KCNH2 (0.51) | KCNH2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893599-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006134378-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |