Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 8/20 | 0.35 |
| ▸ | PDE4A | P27815 | 4/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 3/20 | 0.32 |
| ▸ | HTR2B | P41595 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL915621 | 1.00 | PDE4D (0.35) | PDE4DPDE4APDE4BPDE4CTBK1 | |
| SCHEMBL917771 | 0.95 | PDE4D (0.37) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL916594 | 0.94 | PDE4D (0.37) | PDE4DPDE4APDE4BPDE4CTBK1 | |
| SCHEMBL3552083 | 0.88 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL3548951 | 0.87 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL916752 | 0.87 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL3547325 | 0.85 | GRM2 (0.32) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL917988 | 0.84 | PDE4D (0.37) | PDE4DPDE4APDE4BPDE4CTBK1 | |
| SCHEMBL3671210 | 0.84 | PDE4A (0.48) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL3672015 | 0.83 | PDE4D (0.35) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008035315-A9 | INHIBITORS OF PHOSPHODIESTERASE TYPE-IV | RANBAXY LAB LTD (IN) | 2008-10-23 | — | — | WO | disclosed |