Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT4 | P35916 | 4/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.66 |
| ▸ | FLT3 | P36888 | 3/20 | 0.66 |
| ▸ | AURKA | O14965 | 12/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.53 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.53 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2048731 | 0.92 | FLT4 (0.69) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL2053593 | 0.91 | FLT4 (0.69) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL3427124 | 0.91 | FLT4 (0.69) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL2053380 | 0.90 | FLT4 (0.66) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL2052919 | 0.89 | FLT4 (0.66) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL2053181 | 0.88 | AURKA (0.64) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL2048943 | 0.88 | AURKA (0.66) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL2048821 | 0.88 | AURKA (0.73) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL3429594 | 0.88 | AURKA (0.64) | FLT4PDGFRBFLT3AURKACSF1R | |
| SCHEMBL6032541 | 0.88 | AURKA (0.59) | FLT4PDGFRBFLT3AURKACSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613619-B1 | QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-03-26 | — | — | EP | disclosed |