Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 7/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.62 |
| ▸ | FLT4 | P35916 | 6/20 | 0.62 |
| ▸ | AURKA | O14965 | 9/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.52 |
| ▸ | KDR | P35968 | 6/20 | 0.52 |
| ▸ | EGFR | P00533 | 4/20 | 0.52 |
| ▸ | KIT | P10721 | 4/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | LYN | P07948 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.52 |
| ▸ | HCK | P08631 | 2/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.52 |
| ▸ | MST1R | Q04912 | 2/20 | 0.52 |
| ▸ | MAP2K5 | Q13163 | 2/20 | 0.52 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.52 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.52 |
| ▸ | FLT1 | P17948 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5133213 | 0.95 | FLT3 (0.62) | FLT3PDGFRBFLT4AURKAAURKB | |
| SCHEMBL2048938 | 0.90 | AURKA (0.69) | FLT3PDGFRBFLT4AURKAAURKB | |
| SCHEMBL5132955 | 0.89 | AURKA (0.55) | FLT3PDGFRBFLT4AURKAAURKB | |
| SCHEMBL2053538 | 0.87 | AURKA (0.69) | FLT3PDGFRBFLT4AURKAAURKB | |
| SCHEMBL2052351 | 0.87 | AURKA (0.65) | FLT3PDGFRBFLT4AURKAAURKB | |
| SCHEMBL5048245 | 0.86 | FLT3 (0.60) | FLT3PDGFRBFLT4AURKAAURKB | |
| SCHEMBL2053145 | 0.86 | FLT3 (0.69) | FLT3PDGFRBFLT4AURKAAURKB | |
| SCHEMBL5132856 | 0.85 | FLT4 (0.77) | FLT3PDGFRBFLT4AURKAAURKB | |
| SCHEMBL5133450 | 0.85 | AURKA (0.54) | FLT3PDGFRBFLT4AURKAAURKB | |
| SCHEMBL5132381 | 0.85 | FLT4 (0.76) | FLT3PDGFRBFLT4AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613619-B1 | QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-03-26 | — | — | EP | claimed |