Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.49 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.49 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.49 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.49 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.46 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3103305 | 0.85 | NPC1 (0.56) | MAPTKDM4ENPC1RAB9APTPN1 | |
| SCHEMBL3095746 | 0.84 | NPC1 (0.57) | KMT2AMAPTKDM4ENPC1RAB9A | |
| SCHEMBL3094728 | 0.84 | PTPN1 (0.62) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL3100026 | 0.82 | NR1H4 (0.48) | RAB9APTPN1SMN1; SMN2HPGD | |
| SCHEMBL3099910 | 0.80 | PTPN1 (0.49) | NPC1RAB9APTPN1SMN1; SMN2 | |
| SCHEMBL3099892 | 0.80 | NPC1 (0.50) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL3091786 | 0.79 | TRPV1 (0.59) | MAPTKDM4ENPC1RAB9AHPGD | |
| SCHEMBL3096842 | 0.78 | MEN1 (0.54) | MEN1KMT2AMAPTHTTKDM4E | |
| SCHEMBL13515597 | 0.78 | NPC1 (0.51) | MEN1KMT2AMAPTHTTNPC1 | |
| SCHEMBL3100715 | 0.77 | PTPN1 (0.43) | MEN1KMT2AMAPTHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912634-A2 | PREPARATION AND USE OF BIPHENYL AMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | Bayer Healthcare, LLC (US) | 2008-04-23 | — | — | EP | claimed |
| WO-2007016538-A2 | PREPARATION AND USE OF BIPHENYL AMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2007-02-08 | — | — | WO | claimed |