Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PRKX | P51817 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4417076 | 0.81 | KDM4E (0.50) | NPSR1POLBHTTRAB9AKDM4E | |
| SCHEMBL5132932 | 0.80 | KDM4E (0.40) | NPSR1POLBHTTKDM4EALDH1A1 | |
| SCHEMBL4427340 | 0.77 | SMN1; SMN2 (0.44) | NPSR1POLBHTTRAB9AKDM4E | |
| SCHEMBL5132930 | 0.77 | KDM4E (0.40) | NPSR1POLBHTTKDM4EALDH1A1 | |
| SCHEMBL19439626 | 0.75 | CHEK1 (0.59) | NPSR1HTTCHEK1ABL1PDGFRB | |
| SCHEMBL6429560 | 0.71 | KDM4E (0.42) | NPSR1POLBHTTKDM4EALDH1A1 | |
| SCHEMBL5531200 | 0.71 | CHEK1 (0.54) | HTTCHEK1ABL1PDGFRBPDGFRA | |
| SCHEMBL5131360 | 0.70 | KDM4E (0.41) | NPSR1POLBHTTKDM4EHRH4 | |
| SCHEMBL11370778 | 0.70 | CHEK1 (0.53) | HTTCHEK1ABL1PDGFRBPDGFRA | |
| SCHEMBL4417028 | 0.70 | CHEK1 (0.53) | NPSR1HTTCHEK1ABL1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4077319-B2 | — | — | 2008-04-16 | — | — | JP | claimed |
| EP-1345609-B1 | TETRAHYDRO-(BENZO OR THIENO)-AZEPINE-PYRAZINE AND TRIAZINE DERIVATIVES AS MGLUR 1 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-06-15 | — | — | EP | claimed |
| JP-2004517850-A | — | — | 2004-06-17 | — | — | JP | claimed |
| EP-1345609-A1 | TETRAHYDRO-(BENZO OR THIENO)-AZEPINE-PYRAZINE AND TRIAZINE DERIVATIVES AS MGLUR 1 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-09-24 | — | — | EP | claimed |
| US-6586422-B2 | For therapy and prophylaxis of acute and/or chronic neurological disorders | HOFFMAN-LA ROCHE INC. | 2003-07-01 | — | — | US | claimed |
| US-20020123488-A1 | Pyrazine and triazine derivatives of 1,2,4,5-tetrahydro-Benzo or Thieno [d] azepine | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-05 | — | — | US | claimed |
| WO-2002051418-A1 | TETRAHYDRO-(BENZO OR THIENO)-AZEPINE-PYRAZINE AND TRIAZINE DERIVATIVES AS MGLUR 1 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-04 | — | — | WO | claimed |
| EP-1345609-B1 | TETRAHYDRO-(BENZO OR THIENO)-AZEPINE-PYRAZINE AND TRIAZINE DERIVATIVES AS MGLUR 1 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-06-15 | — | — | EP | disclosed |
| EP-1345609-A1 | TETRAHYDRO-(BENZO OR THIENO)-AZEPINE-PYRAZINE AND TRIAZINE DERIVATIVES AS MGLUR 1 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-09-24 | — | — | EP | disclosed |
| US-6586422-B2 | For therapy and prophylaxis of acute and/or chronic neurological disorders | HOFFMAN-LA ROCHE INC. | 2003-07-01 | — | — | US | disclosed |
| US-20020123488-A1 | Pyrazine and triazine derivatives of 1,2,4,5-tetrahydro-Benzo or Thieno [d] azepine | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-05 | — | — | US | disclosed |
| WO-2002051418-A1 | TETRAHYDRO-(BENZO OR THIENO)-AZEPINE-PYRAZINE AND TRIAZINE DERIVATIVES AS MGLUR 1 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020123488-A1 | Pyrazine and triazine derivatives of 1,2,4,5-tetrahydro-Benzo or Thieno [d] azepine | GRM5, GRIK5, GRM1 | NPSR1 161/4885POLB 4831/4885HTT 1208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.