Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.68 |
| ▸ | CSF1R | P07333 | 1/20 | 0.68 |
| ▸ | KIT | P10721 | 1/20 | 0.68 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | AURKA | O14965 | 16/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.56 |
| ▸ | FLT4 | P35916 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5133625 | 1.00 | PDGFRB (0.68) | PDGFRBCSF1RKITPDGFRACYP3A4 | |
| SCHEMBL5133943 | 0.92 | PDGFRB (0.68) | PDGFRBCSF1RKITPDGFRACYP3A4 | |
| SCHEMBL2049234 | 0.92 | PDGFRB (0.79) | PDGFRBCSF1RKITPDGFRACYP3A4 | |
| SCHEMBL5048615 | 0.92 | PDGFRB (0.68) | PDGFRBCSF1RKITPDGFRACYP3A4 | |
| SCHEMBL6026826 | 0.92 | PDGFRB (0.79) | PDGFRBCSF1RKITPDGFRACYP3A4 | |
| SCHEMBL3428320 | 0.92 | PDGFRB (0.79) | PDGFRBCSF1RKITPDGFRACYP3A4 | |
| SCHEMBL5133601 | 0.91 | AURKA (0.63) | PDGFRBCSF1RKITPDGFRACYP3A4 | |
| SCHEMBL5131914 | 0.90 | AURKA (0.70) | PDGFRBCSF1RKITPDGFRACYP3A4 | |
| SCHEMBL5131974 | 0.90 | AURKA (0.70) | PDGFRBCSF1RKITPDGFRACYP3A4 | |
| SCHEMBL5132487 | 0.90 | AURKA (0.67) | PDGFRBCSF1RKITPDGFRACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1613619-B1 | QUINAZOLINE DERIVATIVES FOR TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-03-26 | — | — | EP | claimed |