Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 4/20 | 0.51 |
| ▸ | AURKA | O14965 | 3/20 | 0.51 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.51 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 5/20 | 0.44 |
| ▸ | CIT | O14578 | 6/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | CHUK | O15111 | 2/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PAK4 | O96013 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4086844 | 0.87 | GRM4 (0.51) | AURKBAURKAINCENPTPX2GRM4 | |
| Trifluoroacetic Acid SCHEMBL4099438 | 0.85 | CIT (0.52) | AURKBAURKAINCENPTPX2GRM4 | |
| Trifluoroacetic Acid SCHEMBL4087373 | 0.85 | GRM4 (0.53) | AURKBAURKAINCENPTPX2GRM4 | |
| Trifluoroacetic Acid SCHEMBL4082197 | 0.84 | AURKB (0.53) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL99923 | 0.84 | AURKA (0.55) | AURKBAURKAINCENPTPX2GRM4 | |
| Trifluoroacetic Acid SCHEMBL2145319 | 0.82 | JAK2 (0.50) | AURKBAURKAINCENPTPX2GRM4 | |
| Trifluoroacetic Acid SCHEMBL101399 | 0.82 | JAK2 (0.50) | AURKBAURKAINCENPTPX2GRM4 | |
| Trifluoroacetic Acid SCHEMBL100282 | 0.82 | JAK2 (0.50) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL102702 | 0.80 | GRM4 (0.56) | AURKBAURKAINCENPTPX2GRM4 | |
| SCHEMBL29540177 | 0.80 | GRM4 (0.56) | AURKBAURKAINCENPTPX2GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966202-A1 | HETEROARYL SUBSTITUTED PYRROLOÝ2,3-B¨PYRIDINES AND PYRROLOÝ2,3-B¨PYRIMIDINES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007070514-A1 | HETEROARYL SUBSTITUTED PYRROLO[2,3-B]PYRIDINES AND PYRROLO[2,3-B]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2007-06-21 | — | — | WO | disclosed |