Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 4/20 | 0.35 |
| ▸ | CTSD | P07339 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4519240 | 0.85 | BACE1 (0.40) | BACE1BACE2CTSD | |
| SCHEMBL4533704 | 0.79 | BACE1 (0.62) | BACE1BACE2CTSD | |
| Hydrochloric Acid SCHEMBL5137186 | 0.73 | BACE1 (0.38) | BACE1BACE2CTSD | |
| SCHEMBL4530723 | 0.72 | BACE1 (0.40) | BACE1BACE2CTSD | |
| SCHEMBL5134308 | 0.71 | BACE1 (0.43) | BACE1BACE2CTSD | |
| SCHEMBL4520792 | 0.71 | BACE1 (0.43) | BACE1BACE2CTSD | |
| SCHEMBL5135553 | 0.70 | BACE1 (0.42) | BACE1BACE2CTSD | |
| SCHEMBL4520910 | 0.70 | BACE1 (0.40) | BACE1BACE2CTSD | |
| Hydrochloric Acid SCHEMBL4785825 | 0.70 | BACE1 (0.36) | BACE1BACE2CTSD | |
| SCHEMBL4520245 | 0.70 | BACE1 (0.46) | BACE1BACE2CTSDKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979324-A2 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER'S DISEASE, NEURODEGENERATION AND DEMENTIA | Astra Zeneca AB (SE) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007058602-A2 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER’S DISEASE, NEURODEGENERATION AND DEMENTIA. | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | disclosed |