Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 4/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRG | P48443 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARD | Q03181 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.30 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.30 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1588214 | 0.94 | CETP (0.41) | CETPARLTC4SS1PR1PLK1 | |
| SCHEMBL1587422 | 0.87 | AR (0.37) | CETPARLTC4SS1PR1PLK1 | |
| SCHEMBL1588409 | 0.87 | CETP (0.46) | CETPARLTC4SS1PR1PPARG | |
| SCHEMBL1588099 | 0.86 | CETP (0.45) | CETPARLTC4SS1PR1PPARG | |
| SCHEMBL1588361 | 0.81 | AR (0.41) | CETPARLTC4SPLK1MRGPRX4 | |
| SCHEMBL1588098 | 0.81 | CETP (0.40) | CETPARLTC4SPPARDPPARA | |
| SCHEMBL12051454 | 0.80 | AR (0.42) | CETPARPLK1 | |
| SCHEMBL12775280 | 0.80 | AR (0.42) | CETPARLTC4SPLK1 | |
| SCHEMBL1587729 | 0.80 | AR (0.41) | CETPARLTC4SPLK1 | |
| SCHEMBL1587798 | 0.79 | CETP (0.39) | CETPARLTC4SS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979331-A1 | TRISUBSTITUTED AMINE COMPOUNDS AS INHIBITORS OF -CHOLESTERYL ESTER TRANSFER PROTEIN CETP | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007088996-A1 | TRISUBSTITUTED AMINE COMPOUNDS AS INHIBITORS OF -CHOLESTERYL ESTER TRANSFER PROTEIN CETP | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-08-09 | — | — | WO | disclosed |