Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | EBP | Q15125 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5135188 | 0.97 | MEN1 (0.42) | MEN1KMT2AC5AR1KDM4ECYP1A2 | |
| SCHEMBL5137523 | 0.97 | MEN1 (0.47) | MEN1KMT2AC5AR1KDM4ECYP1A2 | |
| SCHEMBL5135387 | 0.97 | MEN1 (0.43) | MEN1KMT2AC5AR1KDM4ECYP1A2 | |
| SCHEMBL5135719 | 0.95 | KDM4E (0.41) | MEN1KMT2AC5AR1KDM4ECYP1A2 | |
| SCHEMBL5146342 | 0.95 | C5AR1 (0.44) | MEN1KMT2AC5AR1KDM4ECYP1A2 | |
| SCHEMBL649655 | 0.93 | C5AR1 (0.47) | MEN1KMT2AC5AR1BCHEL3MBTL1 | |
| SCHEMBL5070097 | 0.90 | TP53 (0.48) | MEN1KMT2AC5AR1KDM4ECYP3A4 | |
| SCHEMBL651447 | 0.89 | C5AR1 (0.46) | C5AR1KDM4ECYP3A4MAPK1HSD17B10 | |
| SCHEMBL648191 | 0.89 | C5AR1 (0.46) | MEN1KMT2AC5AR1KDM4ECYP3A4 | |
| SCHEMBL651343 | 0.89 | C5AR1 (0.47) | MEN1KMT2AC5AR1BCHEL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |