Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.61 |
| ▸ | BACE2 | Q9Y5Z0 | 7/20 | 0.59 |
| ▸ | CTSD | P07339 | 4/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4526010 | 0.92 | BACE1 (0.66) | BACE1BACE2CTSD | |
| SCHEMBL4519123 | 0.84 | BACE1 (0.76) | BACE1BACE2CTSD | |
| SCHEMBL4510689 | 0.84 | BACE1 (0.76) | BACE1BACE2CTSD | |
| SCHEMBL4528331 | 0.82 | BACE1 (0.59) | BACE1BACE2CTSD | |
| SCHEMBL4525208 | 0.82 | BACE1 (0.56) | BACE1BACE2CTSD | |
| SCHEMBL4524299 | 0.80 | BACE1 (0.77) | BACE1BACE2CTSD | |
| SCHEMBL13778598 | 0.79 | BACE1 (0.91) | BACE1BACE2CTSD | |
| SCHEMBL4516947 | 0.79 | BACE1 (0.48) | BACE1BACE2CTSD | |
| SCHEMBL8240404 | 0.79 | BACE1 (0.89) | BACE1BACE2CTSD | |
| SCHEMBL8237937 | 0.78 | BACE1 (1.00) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979324-A2 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER'S DISEASE, NEURODEGENERATION AND DEMENTIA | Astra Zeneca AB (SE) | 2008-10-15 | — | — | EP | claimed |
| WO-2007058602-A2 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER’S DISEASE, NEURODEGENERATION AND DEMENTIA. | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | claimed |