Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 11/20 | 0.64 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | PTGES | O14684 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5355102 | 0.89 | LPAR1 (0.55) | LPAR1LPAR5KMT2AMEN1TDP1 | |
| SCHEMBL707436 | 0.84 | LPAR1 (0.82) | LPAR1LPAR5 | |
| SCHEMBL5401485 | 0.83 | LPAR1 (0.53) | LPAR1LPAR5KMT2AMEN1TDP1 | |
| SCHEMBL5399052 | 0.80 | LPAR1 (0.50) | LPAR1LPAR5KMT2AMEN1TDP1 | |
| SCHEMBL5394093 | 0.79 | TP53 (0.51) | LPAR1LPAR5KMT2AMEN1TDP1 | |
| SCHEMBL5411801 | 0.79 | LPAR1 (0.54) | LPAR1LPAR5TSHR | |
| SCHEMBL706511 | 0.79 | LPAR1 (1.00) | LPAR1LPAR5 | |
| SCHEMBL5364503 | 0.78 | TDP1 (0.70) | LPAR1KMT2AMEN1TDP1TSHR | |
| SCHEMBL5418271 | 0.77 | LPAR1 (0.53) | LPAR1LPAR5KMT2AMEN1TDP1 | |
| SCHEMBL5402272 | 0.77 | MEN1 (0.49) | LPAR1LPAR5KMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |