Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 5/20 | 0.36 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5134517 | 0.93 | PPARG (0.43) | PPARGPPARAMAPTTLR7BCHE | |
| SCHEMBL5135533 | 0.91 | PPARG (0.44) | PPARGPPARAMAPTNPBWR1C5AR1 | |
| SCHEMBL648541 | 0.91 | BCHE (0.42) | PPARGPPARAMAPTTLR7BCHE | |
| SCHEMBL5072389 | 0.90 | TSHR (0.41) | PPARGPPARAC5AR1TSHRHPGD | |
| SCHEMBL5137333 | 0.90 | BCHE (0.44) | PPARGPPARAMAPTBCHEC5AR1 | |
| SCHEMBL5135729 | 0.90 | PPARG (0.40) | PPARGPPARAMAPTC5AR1TSHR | |
| SCHEMBL5137856 | 0.87 | C5AR1 (0.39) | PPARGPPARABCHEC5AR1TSHR | |
| SCHEMBL5134565 | 0.86 | PPARG (0.42) | PPARGPPARAMAPTTLR7NPBWR1 | |
| SCHEMBL5137298 | 0.86 | PPARG (0.39) | PPARGPPARAMAPTNPBWR1C5AR1 | |
| SCHEMBL5072207 | 0.86 | PPARG (0.39) | PPARGPPARAC5AR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |