Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.56 |
| ▸ | GNRHR | P30968 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | ATP4A | P20648 | 2/20 | 0.37 |
| ▸ | ATP4B | P51164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5134900 | 0.95 | C5AR1 (0.63) | C5AR1GNRHRALDH1A1MAPTKDM4E | |
| SCHEMBL5135332 | 0.94 | C5AR1 (0.59) | C5AR1GNRHRALDH1A1MAPTKDM4E | |
| SCHEMBL5135936 | 0.93 | C5AR1 (0.63) | C5AR1GNRHRALDH1A1MAPTKDM4E | |
| SCHEMBL5071329 | 0.91 | C5AR1 (0.60) | C5AR1GNRHRALDH1A1MAPTKDM4E | |
| SCHEMBL5136601 | 0.90 | C5AR1 (0.58) | C5AR1GNRHRMAPTGAASMN1; SMN2 | |
| SCHEMBL5073846 | 0.90 | C5AR1 (0.58) | C5AR1GNRHRALDH1A1MAPTKDM4E | |
| SCHEMBL648955 | 0.90 | C5AR1 (0.58) | C5AR1GNRHRALDH1A1KDM4EHPGD | |
| SCHEMBL5136554 | 0.90 | C5AR1 (0.58) | C5AR1GNRHRMAPTKDM4EGAA | |
| SCHEMBL5135734 | 0.90 | C5AR1 (0.63) | C5AR1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL4768447 | 0.90 | C5AR1 (0.64) | C5AR1GNRHRALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490044-A4 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORP (US) | 2008-04-16 | — | — | EP | disclosed |
| EP-1490044-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084524-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CONDITIONS WITH PATHOGENIC INFLAMMATORY COMPONENTS | NEUROGEN CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |