Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4469601 | 0.88 | KCNA5 (0.42) | KCNA5CYP19A1PFKFB3PDE4DKMT2A | |
| SCHEMBL4457212 | 0.83 | KCNA5 (0.42) | KCNA5CYP19A1PDE4DKMT2AALDH1A1 | |
| SCHEMBL4461880 | 0.81 | KCNA5 (0.35) | KCNA5CYP19A1PFKFB3PDE4DPIK3CA | |
| SCHEMBL4461835 | 0.80 | CYP19A1 (0.40) | KCNA5CYP19A1PDE4DKMT2AALDH1A1 | |
| SCHEMBL4457667 | 0.79 | KMT2A (0.39) | KCNA5CYP19A1KMT2AALDH1A1POLB | |
| SCHEMBL4454542 | 0.78 | CYP19A1 (0.45) | KCNA5CYP19A1KMT2AMEN1 | |
| SCHEMBL4472869 | 0.78 | CYP19A1 (0.48) | KCNA5CYP19A1PFKFB3 | |
| SCHEMBL4470602 | 0.77 | KCNA5 (0.35) | KCNA5CYP19A1PFKFB3PDE4DKMT2A | |
| SCHEMBL4468118 | 0.76 | KCNA5 (0.36) | KCNA5CYP19A1PDE4DKMT2AALDH1A1 | |
| SCHEMBL4472165 | 0.76 | CYP19A1 (0.45) | KCNA5CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981507-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007089679-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2007-08-09 | — | — | WO | disclosed |